Wuxi, located at 31°7'-32°2' and 119°33'-120°38'E, lies in the southeastern Jiangsu Province. Abutting the picturesque Taihu Lake, it belongs to the economically developed Yangtze River Delta. It has Suzhou to the east; is 128 km from Shanghai; faces Taihu Lake in the south; neighbors Zhejiang Province; abuts Changzhou in the west; is 183 km from Nanjing; has the Yangtze River in the north; and commands 35 km of the golden Yangtze River bank.

Wuxi is in the plain area, dotted with sporadic low-lying mountains and hills. Its southern part is a plain cut by many rivers; its central part is composed of low-lying paddy fields surrounded by dykes; and its southwestern part features low mountains and a hilly area in Yixing. Mountainous and hilly areas total 782 square km, making up 16.8 percent of the total area; water covers an area of 1,502 square km, making up 31.4 percent of the total.